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The principal cytochrome P450 isoenzyme involved appears being CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Around eighty five% of an oral dose appears from the urine within 24 hours of administration, most as being the glucuronide conjugate, with smaller amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity details.The h